1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate

1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate - Names and Identifiers

Name	1-tert-butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate
Synonyms	Ethyl N-Boc-3-Oxopiperidine-4-carboxylate Ethyl 1-N-Boc-3-oxopiperidine-4-carboxylate 3-Oxo-piperidine-1-carboxylic acid tert-butyl este 1-tert-butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate 1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate 1-(tert-butoxycarbonyl)-4-ethyl-3-oxopiperidine-4-carboxylic acid 3-Oxo-Piperidine-1,4-Dicarboxylic Acid 1-Tert-Butyl Ester 4-Ethyl Ester 1-tert-butyl 4-ethyl 3-hydroxy-5,6-dihydropyridine-1,4(2H)-dicarboxylate 1,4-Piperidinedicarboxylic acid, 3-oxo-, 1-(1,1-diMethylethyl) 4-ethyl ester
CAS	71233-25-5
InChI	InChI=1/C13H21NO5/c1-5-18-11(16)9-6-7-14(8-10(9)15)12(17)19-13(2,3)4/h9H,5-8H2,1-4H3

1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate - Physico-chemical Properties

Molecular Formula	C13H21NO5
Molar Mass	271.31
Density	1.152±0.06 g/cm3(Predicted)
Boling Point	364.6±42.0 °C(Predicted)
Flash Point	174.3°C
Vapor Presure	1.66E-05mmHg at 25°C
Appearance	Liquid
pKa	11.17±0.20(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.482
MDL	MFCD09878815

1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate - Introduction

1-tert-butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate, also known as 1-tert-butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate, is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
-Chemical formula: C16H25NO5
-Molecular weight: 311.37g/mol
-Appearance: colorless to yellowish liquid or solid
-Solubility: Soluble in common organic solvents, such as ether, dimethylformamide and dichloromethane, almost insoluble in water.

Use:
1-tert-butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate is commonly used in organic synthesis as a protecting group. The compound is capable of protecting the amine functional group in order to perform other chemical transformations under specific reaction conditions, with minor interference with the reactivity of the amine group. Once desired, the protecting group can be removed by appropriate conditions.

Preparation Method:
The preparation of 1-tert-butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate is usually carried out by the following steps:
1. piperidine is reacted with ethyl chloroacetate to generate 3-oxo piperidine.
2. the reaction of 3-oxo piperidine with tetrabutylammonium trifluorosilicate generates the corresponding N-BOC protected amide.
3. Finally, the N-BOC protected amide is reacted with dimethyl acetate to generate the final 1-tert-butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate.

Safety Information:
1-tert-butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate is a chemical reagent, and relevant safety procedures should be followed during operation. It may be irritating to the eyes, skin and respiratory system and must be avoided. During use and storage, attention should be paid to avoid fire and high temperature. At the same time, it should be kept away from oxidants and strong acids. If necessary, operate in a well-ventilated environment and wear suitable protective equipment.

Last Update：2024-04-10 22:29:15